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Description:
Biochem/physiol Actions
Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharide s, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.
Mode of Resistance: The activity of Polymyxin B sulfate is inhibited by iron(II), Co(II), Mn(II) and Magnesium ions. Polymyxin B may also be incompaitible with other microbial agents, including amphoterecin, cephalothin sodium, cephasolin sodium and heparin sodium.
Antimicrobial Spectrum: Has bactericidal action on most gram -negative bacilli, including E. Coli and on most fungi and gram-positive bacteria.
Specification:
1ml x 10 bottles